Orbitofrontal cortex dysfunction in abstinent cocaine abusers performing a decision-making task
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منابع مشابه
Orbitofrontal cortex dysfunction in abstinent cocaine abusers performing a decision-making task.
Cocaine abusers demonstrate faulty decision-making as manifested by their inability to discontinue self-destructive drug-seeking behaviors. The orbitofrontal cortex (OFC) plays an important role in decision-making. In this preliminary study we tested whether 25-day-abstinent cocaine abusers show alterations in normalized cerebral blood flow (rCBF) in the OFC using PET with (15)O during the Iowa...
متن کاملPrefrontal cortical dysfunction in abstinent cocaine abusers.
The anterior cingulate cortex (ACC) and lateral prefrontal (LPFC) cortex are brain regions important to executive cognitive functions (ECF). We determined ACC and LPFC function in 23-day abstinent cocaine abusers using positron emission tomography (PET H(2)(15)O) during performance of a modified version of the Stroop Task. Cocaine abusers showed less activation than non-drug-using comparison su...
متن کاملOrbitofrontal cortex, decision-making and drug addiction.
The orbitofrontal cortex, as a part of prefrontal cortex, is implicated in executive function. However, within this broad region, the orbitofrontal cortex is distinguished by its unique pattern of connections with crucial subcortical associative learning nodes, such as basolateral amygdala and nucleus accumbens. By virtue of these connections, the orbitofrontal cortex is uniquely positioned to ...
متن کاملEmotion, decision making and the orbitofrontal cortex.
The somatic marker hypothesis provides a systems-level neuroanatomical and cognitive framework for decision making and the influence on it by emotion. The key idea of this hypothesis is that decision making is a process that is influenced by marker signals that arise in bioregulatory processes, including those that express themselves in emotions and feelings. This influence can occur at multipl...
متن کاملCognitive modeling analysis of decision-making processes in cocaine abusers.
This article examines the theoretical basis of decision-making deficits exhibited by cocaine abusers in a laboratory decision-making task first described by Bechara, Damasio, Damasio, and Anderson (1994). A total of 12 male cocaine abusers and 14 comparison subjects performed the task, and the cocaine group performed significantly worse than the comparison group. A cognitive modeling analysis (...
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ژورنال
عنوان ژورنال: NeuroImage
سال: 2003
ISSN: 1053-8119
DOI: 10.1016/s1053-8119(03)00113-7